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PHR1583

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Megestrol Acetate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Megestrol acetate, 17α-Acetoxy-6-methyl-4,6-pregnadiene-3,20-dione, 17α-Hydroxy-6-methyl-4,6-pregnadiene-3,20-dione 17-acetate, 17α-Hydroxy-6-methyl-6-dehydroprogesterone 17-acetate, Megestrol 17-acetate

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About This Item

Empirical Formula (Hill Notation):
C24H32O4
CAS Number:
595-33-5
Molecular Weight:
384.51
Beilstein/REAXYS Number:
1917291
EC Number:
209-864-5
MDL number:
MFCD00056470
UNSPSC Code:
41116107
PubChem Substance ID:
329823491
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 223
traceable to Ph. Eur. Y0001514
traceable to USP 1379106

API family

megesterol

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C

InChI

1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1

InChI key

RQZAXGRLVPAYTJ-GQFGMJRRSA-N

Gene Information

human ... PGR(5241)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Megestrol Acetate is a progestogen drug indicated for the palliative treatment of endometrial carcinoma and breast cancer. The administration of the drug is usually done orally as a solid dosage form.

Application

Megestrol Acetate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, oral contraceptives and suspensions by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA4562 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1379106

Megestrol acetate, United States Pharmacopeia (USP) Reference Standard

N1080005

Nomegestrol acetate impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001594

Megestrol acetate impurity K, European Pharmacopoeia (EP) Reference Standard

Y0001514

Megestrol acetate, European Pharmacopoeia (EP) Reference Standard

Y0001507

Megestrol acetate for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0001524

Megestrol acetate for system suitability, European Pharmacopoeia (EP) Reference Standard

1379128

Megestrol Acetate Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP223

Megestrol acetate, British Pharmacopoeia (BP) Reference Standard

1379139

Megestrol Acetate Related Compound D, United States Pharmacopeia (USP) Reference Standard

1379172

Megesterol Acetate Related Compound H, United States Pharmacopeia (USP) Reference Standard

BP222

Megestrol, British Pharmacopoeia (BP) Reference Standard

Y0002161

Nomegestrol acetate for ID and assay CRS, CRS, European Pharmacopoeia (EP) Reference Standard

Y0002169

Nomegestrol acetate impurity B, CRS, European Pharmacopoeia (EP) Reference Standard

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC1632
LRAA4562

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Food effect on the bioavailability of two distinct formulations of megestrol acetate oral suspension
Deschamps B, et al.
International journal of nanomedicine, 4, 185-185 (2009)
Jianghuan Hua et al.
Ecotoxicology and environmental safety, 163, 289-297 (2018-07-30)
Synthetic progestins are widely used pharmaceutical agents that have become common contaminants in the aquatic environment. The potential adverse effects of long-term exposure on aquatic wildlife, however, are not fully understood. The aim of this study was to investigate the
Improved bioavailability of a micronized megestrol acetate tablet formulation in humans
Farinha A, et al.
Drug Development and Industrial Pharmacy, 26(5), 567-570 (2000)
Thin-layer chromatographic identification of estrogens and progestogens in oral contraceptives
Simard MB and Lodge BA
Journal of Chromatography A, 51, 517-524 (1970)
Medroxyprogesterone Acetate
USP42-NF37
United States Pharmacopeia/National Formulary, 42(6), 2715-2715 (2018)
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