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PHR1690

Supelco

Disulfiram

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Tetraethylthiuram disulfide, Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Linear Formula:
(C2H5)2NCSS2CSN(C2H5)2
CAS Number:
97-77-8
Molecular Weight:
296.54
Beilstein/REAXYS Number:
1712560
EC Number:
202-607-8
MDL number:
MFCD00009048
UNSPSC Code:
41116107
PubChem Substance ID:
329823558
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 132
traceable to Ph. Eur. D2950000
traceable to USP 1224008

API family

disulfiram

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

69-71 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCN(CC)C(=S)SSC(=S)N(CC)CC

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

InChI key

AUZONCFQVSMFAP-UHFFFAOYSA-N

Gene Information

human ... ALDH2(217)

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Disulfiram is clinically used in the treatment of chronic alcoholism.

Application

Disulfiram may be used as a pharmaceutical reference standard for the determination of the analyte in biological fluids and pharmaceutical formulations by high performance liquid chromatography and spectrophotometry, respectively.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Alcohol dehydrogenase inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2079 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC2079
LRAB3697
LRAA6757

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Simultaneous determination of disulfiram and two of its dithiocarbamate metabolites in human plasma by reversed-phase liquid chromatography
Masso PD, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 224(3), 457-464 (1981)
Determination of disulfiram and metabolites from biological fluids by high-performance liquid chromatography
Jensen JC, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 181(3-4), 407-416 (1980)
Spectrophotometric determination of methimazole, D-penicillamine, captopril, and disulfiram in pure form and drug formulations
Skowron M and Ciesielski W
Journal of Analytical Chemistry, 66(8), 714-719 (2011)

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