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SAB5500139

Sigma-Aldrich

Anti-MAGE-A1 antibody, Rabbit monoclonal

clone SP188, recombinant, expressed in proprietary host, affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

SP188, monoclonal

species reactivity

human (tested)

technique(s)

flow cytometry: 1:400
immunoblotting: 1:400
immunohistochemistry: 1:100

isotype

IgG

UniProt accession no.

P43355

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... MAGEA1(4100)

Related Categories

General description

Melanoma-associated antigen 1 (MAGE-A1) is a member of the MAGE family. It is encoded by the gene mapped to human chromosome Xq28.
Melanoma-associated antigen 1 (MAGE-A1) is one of the melanoma associated antigens (MAAs). MAGE-A1 is highly expressed in testis and some human solid tumors such as melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian and renal cell carcinomas.

Immunogen

Synthetic peptide derived from the C-terminus of human MAGE-A1 protein.

Biochem/physiol Actions

Members of MAGE family play a vital role in maintaining normal cellular physiology. Melanoma-associated antigen 1 (MAGE-A1) serves as a target antigen of patient-derived CD8+ T cells in melanoma. It might be potential target for treating melanoma patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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MAGE-A1 promotes melanoma proliferation and migration through C-JUN activation.
Wang D, et al.
Biochemical and Biophysical Research Communications, 473(4), 959-965 (2016)
MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily.
Stone B, et al.
Gene, 267(2), 173-182 (2001)

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