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SAB5500140

Sigma-Aldrich

Anti-MAGE-A1 antibody, Rabbit monoclonal

clone SP194, recombinant, expressed in proprietary host, affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

SP194, monoclonal

species reactivity

human (tested)

technique(s)

flow cytometry: 1:400
immunoblotting: 1:400
immunohistochemistry: 1:100

isotype

IgG

UniProt accession no.

P43355

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... MAGEA1(4100)

Related Categories

General description

Melanoma-associated antigen 1 (MAGE-A1) belongs to the melanoma-associated antigen (MAGE) gene family. It is also termed cancer-testis antigen (CTA) or cancer-germline (CG) gene. The MAGE-A1 gene is mostly expressed in the human germline. It is also expressed in the placenta and various tumor cells. MAGE-A1 gene is located on human chromosome Xq28.

Immunogen

Synthetic peptide derived from the C-terminus of human MAGE-A1 protein.

Biochem/physiol Actions

Melanoma-associated antigen 1 (MAGE-A1) stimulates the proliferation and colony formation of melanoma cells. It might modulate the oncogenic C-JUN expression either directly or via the extracellular-signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) signaling pathway. Hence, MAGE-A1 could be a possible therapeutic target for patients with melanoma. It can be a potential marker in the treatment of lung adenocarcinoma (LUAD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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