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SML0031

Sigma-Aldrich

DBeQ

≥98% (HPLC)

Synonym(s):

JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine

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About This Item

Empirical Formula (Hill Notation):
C22H20N4
CAS Number:
177355-84-9
Molecular Weight:
340.42
MDL number:
MFCD03691820
UNSPSC Code:
12352200
PubChem Substance ID:
329825101
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4

InChI

1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

InChI key

QAIMUUJJAJBPCL-UHFFFAOYSA-N

Application

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Biochem/physiol Actions

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

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