SRP0430
PDE4A4B active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE)
Synonym(s):
DPDE2, PDE46, phosphodiesterase 4A, cAMP-specific
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥40% (SDS-PAGE)
form
aqueous solution
mol wt
124 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PDE4A(5141)
General description
Human PDE4A4B, also known as PDE4A isoform 1 (GenBank Accession No. NM_001111307) amino acids 2-end with N-terminal GST-tag, MW= 124 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Unit Definition
One unit is defined as the amount of enzyme that will convert 1 pmole of 3?, 5?-cAMP to 5?-AMP per min at 37°C.
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Sullivan,M., et al.
Journal of Biochemistry, J. 333, 693-703 (1998)
Elaine Huston et al.
Journal of cell science, 119(Pt 18), 3799-3810 (2006-08-31)
The unique N-terminal regions of PDE4 cAMP-specific phosphodiesterases confer interaction with distinct signalling and scaffolding proteins. The PDE4A1 isoform is unique in being entirely membrane associated. Its N-terminal region is formed from two helices separated by a mobile hinge, where
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